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COLDSTORM® COLD & FLU RESCUE

MONOGRAPH COLDSTORM® Cold & Flu Rescue

NPN: 80079905 

Indication: Traditionally used in Herbal Medicine to help relieve the symptoms associated with upper respiratory tract infections and catarrhal conditions.

Dosage: Adults, nursing mothers, and adolescents take 2-3 ml up to 3 times daily. Children 2-9 years old; take 1 ml up to 3 times daily.

1 mL of COLDSTORM® contains the medicinal ingredient Garlic (Allium sativum, bulb, fresh): 660 mg

Non-medicinal ingredients: glycerin, ethanol, cherry juice, natural mint flavour. 

Detailed Information:

COLDSTORM® is formulated with fresh garlic bulb using a proprietary extraction method. The recommended daily dosage of COLDSTORM® drops can be taken by the whole family, including:

• Pregnant women*

• Nursing mothers*

• Children 2-9 years old

• Adolescents 10-18 years old

• Adults >19 years old

Plants of the genus Allium are known for their production of organo sulfur compounds, which possess interesting biological and pharmacological properties. Among these, garlic is considered one of the most important herbal medicines, with widespread antimicrobial properties and immune boosting and anti-inflammatory effects(1). The chemistry of garlic is complex. It contains more than 2000 biologically active substances, including volatile, water-soluble and oil-soluble organosulfur compounds, along with essential oils,dietary fiber, sugars, flavonoids and pectin(2).

The Natural and Non-prescription Health Products Directorate (NNHPD)of Health Canada has published a monograph recognizing the traditional use of garlic bulb in Herbal Medicine at 0.5-12 g/day to help relieve the symptoms associated with upper respiratory tract infections and catarrhal conditions, as well as to help reduce elevated blood lipid levels/hyperlipidemia and maintain cardiovascular health in adults(3). Additionally, the WHO Monograph on Allium sativum recognizes its use in the treatment of respiratory and urinary tract infections, ringworm, and rheumatic conditions. The herb is also recognized for its traditional use as a carminative for dyspepsia(4). Garlic bulb is a recognized source of antioxidants in the form of organo sulfur compounds that help protect against the oxidative damage caused by free radicals(5),(6).

Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species in cells and tissues and the ability of a biological system to eliminate or detoxify these reactive products. Free radicals are generated from sources inside and outside of the body. Immune cell activation, inflammation, ischemia, infection, cancer, excessive exercise, mental stress, and aging are all responsible for endogenous free radical production. Exogenous free radical production can occur as a result of exposure to environmental pollutants,heavy metals (Cd, Hg, Pb, Fe, and As), dental metals, certain drugs (e.g.cyclosporine, tacrolimus, gentamycin, bleomycin), vaccines, pesticides, chemical food preservatives, chemical solvents, oxidized cooking oil and hydrogenated fat, cigarette smoke, alcohol, and radiation. When exogenous oxidative compounds enter or penetrate the body, they are degraded or metabolized, and free radicals are generated as by-products. If not strictly controlled, oxidative stress can be responsible for the induction of diseases, both chronic and degenerative, and speed up aging processes in the body and cause acute pathologies (i.e. trauma and stroke)(7). 

Excessive exposure to toxic heavy metals from plants in the diet or persistent organic pollutants (POPs) from the environment is inevitable with increased industrialization and environmental pollution. Oxidative stress and pro-inflammatory actions are the common mechanisms for heavy metal or POP toxicities. However, phyto nutrients can counteract these cellular insults byanti-oxidation, up regulation of anti-inflammatory pathways, and chelation(8). For example, toxic metals have great affinity for sulphur containing peptides. Thus, diets rich in sulphur-containing foods such as alliums (e.g. garlic) have been suggested for symptomatic improvement and enhanced excretion of toxic metals from the body. Animal models have been used to demonstrate the use of garlic to prevent cadmium-induced kidney damage, and to decrease oxidative damage due to lead(9). Pre-treatment with garlic also prevents degenerative changes otherwise induced by lead, by reducing oxidative stress and the production of cytokines and inflammatory mediators, and by restoring/normalizing biochemical processes occurring in tissues(10). In a clinical study in humans to investigate therapeutic effects of garlic compared with the commonly used chelator d-penicillamine in patients with chronic lead poisoning, after 4 weeks clinical improvement was significant only in the garlic-treatment group,and for a number of clinical manifestations of lead poisoning, including irritability, headache, decreased deep tendon reflex, and mean systolic blood pressure. While blood lead concentrations were significantly reduced in both treatment groups, the frequency of treatment side effects was significantly lowering the garlic treatment group. Treatment with garlic is therefore clinically safer, if not also more effective, than more common chelator treatment for mild-to-moderate lead poisoning in humans(11).

 The benefits of garlic to health have been proclaimed for centuries; however,only recently have Allium sativum and its preparations and constituents been proposed as promising candidates for maintaining or improving immune system function. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences in final composition and proportion of active constituents. An assessment of the most recent experimental results indicates that garlic enhances the functioning of the immune system by stimulating certain immune cell types, such as macrophages,lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils, by various mechanisms, including modulation of cytokine secretion, immunoglobulin production, phagocytosis, autophagy and macrophage activation. Immune dysfunction plays an important role in the development and progress of several diseases. Immune system regulation by garlic extracts can thus contribute to the treatment and prevention of pathologies such as obesity,metabolic syndrome, cardiovascular disorders, and gastric ulcer, among others(1). 

Many consumers take garlic supplements as a preventive, and report an absence of colds and flu or cold and flu symptoms. Clinical trials are supportive, showing garlic to have a beneficial effect in the prevention, duration, and severity of upper respiratory infections. For example, a randomized, double-blind,placebo-controlled trial involving 146 participants testing the effect of 180mg of a garlic powder supplement per day over 3 months found a significant 37%reduction in the number of colds and a 30% reduction in the duration of symptoms in the group taking garlic compared with the placebo group(12). At the end of the 90-day study, 24 colds were reported in the garlic treatment group compared to 65 in the placebo group, the total number of days of infection were significantly reduced (111 vs. 366), and the duration of symptoms in those who contracted colds was also significantly reduced (1.52 vs. 5.01 days). During the study, the 16 volunteers taking the placebo became re-infected(i.e. they experienced more than one full-blown cold); only 2 volunteers taking the garlic supplement reported a re-infection. The results of this study support garlic supplementation to both prevent attack by the common cold virus, and to reduce duration of symptoms in those that do contract a cold(12). Another placebo-controlled human study involving 120 healthy participants supplemented with 2.56 g/day of an aged garlic extract for 90 days during the cold and flu season demonstrated that the reduced severity of the colds and flu reported among participants with dietary garlic supplementation could be at least partly attributed to their enhanced immune cell function.The immune system support, perhaps with less accompanying inflammation(13),(14), and reduced oxidative stress (15) , (16) and metal and POP toxicity warrants the intake of garlic-containing supplements such as COLDSTORM® to combat, if not prevent, cold and flu symptoms.

 Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant*, have diabetes**, or if you are taking blood thinners or protease inhibitors. Consult a healthcare practitioner if symptoms persist or worsen.

Known Adverse Reactions: Hypersensitivity/allergic reactions are known to occur; in which case discontinue use.

*Pregnancy & Nursing mothers: There is no current evidence to suggest that there is any risk of malformation or harmful effects on the foetus with consumption of garlic by pregnant women(17). Out of an abundance of caution Based on at least one clinical study(18), garlic consumption is compatible with nursing(19). The study demonstrated that the ingestion of garlic by nursing mothers significantly and consistently increased the perceived odour intensity of the mother’s milk, which peaked 2-hours after garlic ingestion. Infants detected these changes, as evidenced by increased time of attachment to the mother’s breast and increased suckling when the milk smelled like like garlic, resulting in a tendency for infants to ingest more milk(20). pregnant women can make their doctor aware of their garlic consumption(3).

**Diabetes: Garlic has been shown to enhance the hypoglycemic effects of anti diabetic medication(21). While helping to improve glycemic control and antihyperlipidemic activity, and therefore showing the potential to be a good adjunct in the management of patients with diabetes and hyperlipidemia(19), this action also gives reason to closely monitor blood sugar levels in the event that diabetics can reduce or modify their medication. 

Strauss Naturals™, the exclusive manufacturer of COLDSTORM® , is a GMP-certified, NNHPD-licensed, and a US FDA-inspected manufacturer. Strauss Naturals™ is the sole producer and worldwide supplier of the clinically-supported 20,21, Strauss Heartdrops® herbal formula (NPN 80030089), an alcohol-based extract of aged garlic, hawthorn fruit, hawthorn leaf & flower, cayenne, European mistletoe leaf and bilberry leaf in combination with motherwort and white willow bark. The 8th generation family formula follows an ancient yet revolutionary method of aging and extracting garlic. Aged garlic has profound heart health benefits.

1  Arreola R, Quintero-Fabián S, López-Roa RI, Flores-Gutiérrez EO, Reyes-Grajeda JP, Carrera-Quintanar L, et al. Immunomodulation and anti-inflammatory effects of garlic compounds. J Immunol Res. 2015:401630. 2 Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014;65(1):1-8. 3 NNHPD Monograph on Garlic. July 2017. 4 WHO (World Health Organization). Bulbus Allii Sativi. In: WHO monographs on selected medicinal plants. Volume 1. Geneva, CH: WHO; 1999. Available at: (http://apps.who.int/medicinedocs/en/d/Js2200e/4.html#Js2200e.4). 5 NNHPD Monograph on Antioxidants, August 2017 6 Borek C. Antioxidant health effects of aged garlic extract. J Nutr. 2001; 131:1010S-1015S. 7 Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev. 2017: 8416763. 12 Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001;18(4):189-93. 13 Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, Percival SS. Supplementation with aged garlic extract improves both NK and γδ -T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, 14 Percival SS. Aged Garlic Extract Modifies Human Immunity. J Nutr. 2016 Feb;146(2):433S-436S. 15 NNHPD Monograph on Antioxidants, August 2017. 16 Borek C. Antioxidant health effects of aged garlic extract. J Nutr. 2001; 131: 1010S-1015S. 17 1010S-1015S. 18 Mennella JA, Beauchamp GK. The effects of repeated exposure to garlic- flavored milk on the nursling’s behavior. Pediatr Res. 1993;34(6):805-8. 19 Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011;24(4):565-70. 20 Hornby P. A One-Year Observational Study to Determine the Efficacy and Safety of Strauss Heartdrops in Reducing Risk to Coronary Heart Disease. Study 21 Petrella R, et al. Effect of Herbal Strauss Heartdrops in Patients with Chronic Stable Angina. Study Report. KGK Synergize Inc.; 2005.

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