- Stress & Worry
- Depression & Anxiety
- Adjustment Disorder
- PTSD & Acute Stress Disorder
- Low Serotonin & Melatonin Levels
- Fatigued Adrenal Glands
- Vitamin and Mineral Deficiency
REMSleep’s proprietary blend of vitamins, minerals, amino acids and herbs have been specially formulated to target these common factors of insomnia and facilitate and enhance your best night’s sleep.
REMSleep© is an all-natural sleep aid formula. Our formula contains ingredients that research has shown to help improve and enhance better sleep.
So how can REMSleep© help?
REMSleep© is the most comprehensive, holistic sleep aid available to help ensure a great night’s sleep. For many people, finding the right sleep aid can become a guessing game with a lot of wasted time, money and sleep. What makes REMSleep© unique is that 1) – REMSleep©, unlike other sleep aids, targets many factors that cause and contribute to poor sleep due to its unique blend of vitamins, minerals, amino acids, and herbs and 2) – it’s the only natural sleep aid specifically formulated and developed by a Clinical Psychologist with a mental health background.
Dr. Matthew D. Pfeiffer, creator of REMSleep©, has researched and sampled dozens of natural and over-the-counter sleep aids. As Dr. Pfeiffer researched sleep quality some important conclusions emerged. Poor sleep quality is often caused by multiple factors and sleep aids, both natural and over-the-counter, typically only target
one of those factors.
REMSleep© will help you get the deep sleep you need that will ensure you wake up feeling rested and energized! REMSleep© combination of 100% natural nutraceuticals work together and interact with receptors in the brain believed to help produce and increase the sleep you need to feel your best!
Magnesium Chloride – With most multi-ingredient supplements, there is usually, what I call, a cornerstone ingredient. With REMSleep, the most important ingredient is Magnesium. I chose Magnesium Chloride, as opposed to Magnesium Citrate, Acetate, Carbonate, Threonate, etc., because it has superior bioavailability when taken with or without food, it doesn’t cause a laxative effect like other bonded Magnesium molecules, and it’s molecular size is smaller than most other bonded magnesium molecules, thereby allowing a higher dose of magnesium while maintaining the smallest pill possible. With regard to why Magnesium is considered the cornerstone ingredient in my product, or the most important ingredient, Magnesium regulates over 300 biochemical reactions in the body through their role as enzyme co-factors. Magnesium is one of the most common co-factors in the body. Its presence is crucial to:
• Glucose and fat breakdown
• Production of proteins, enzymes and antioxidants such as Glutathione
• Creation of DNA and RNA
• Regulation of cholesterol production
Without enzyme co-factors—including both hormones and vital minerals such as magnesium—reactions could easily spiral out of control. In fact, even slight imbalances can chronically impact the body’s level of performance and health. Thus, magnesium’s function as an enzyme co-factor can be seen as analogous to the important role that our body’s hormones play, including the sleep hormone melatonin and its synthesis from serotonin. The crucial difference, however, is that our body can manufacture most hormones itself using basic building blocks. Magnesium, on the other hand, cannot be manufactured by the body, it must be taken in, similarly to Vitamin D. Research has shown that even a marginal lack of it can prevent the brain from settling down at night.
L-Taurine – Taurine is an amino acid that reduces cortisol levels and increases the production of GABA, which is a major inhibitory neurotransmitter—our bodies’natural “off” switch. This process of supplementing Taurine, and its natural conversion into GABA, helps to calm the nervous system by lowering stress and anxiety hormones that hinder sleep and increasing inhibitory neurotransmitters that improve sleep.
Calcium Citrate – Calcium is used by the brain to produce the sleep inducing substance melatonin. In one study published in the European Neurology Journal, researchers concluded that disturbances in sleep, especially the absence of REM deep sleep or disturbed REM sleep, are related to a calcium deficiency. Restoration for many individuals to the normal course of sleep was achieved following the normalization of the blood calcium level. I chose Calcium Citrate, as opposed to Carbonate, Acetate, etc., because it has the highest bio-availability when taken with or without food. This type of calcium molecule is often referred to as “Elemental Calcium.”
Calcium D-Pantothenate – Also referred to as Pantothenic Acid or Vitamin B5, this nutrient is good for relieving stress and anxiety. Vitamin B5 is directly linked to the health of your adrenal glands, the small glands that sit on top of your kidneys that secrete hormones like testosterone, estrogen, DHEA, epinephrine, and cortisol. Of the aforementioned hormones, proper secretion of epinephrine and cortisol are especially important to your stress levels. High stress levels and insomnia are commonly related to excessive cortisol in your body due to overworked adrenal glands. Because a pantothenic acid deficiency can affect your adrenal glands, increasing your vitamin B5 intake with certain foods or in supplement form will often help by lowering
your cortisol levels and subsequently alleviating stress and realigning your body’s natural sleep cycles.
Methylcobalamin – Also known as Vitamin B12, is critical for good sleep. Deficiency of vitamin B12 can cause a wide range of health problems, many of which can be mistaken for other disorders. For example, elderly people experiencing cognitive decline may be misdiagnosed with Alzheimer’s disease, when in reality they are suffering the effects of long-term B12 deficiency.
Deficiency of the vitamin is most often because the body’s method of absorbing it is defective, which can result in deadly anemia, sleeping disorders or mental decline. Because B12 is only found in animal foods, vegetarians must be especially careful to supplement their diets with B12 vitamin capsules or injections.
Methylcobalamin is the most active and easily absorbed form of B12, especially when an individual’s ability to absorb B12 is defective. Though the vitamin is available in other forms — such as cyanocobalamin, hydroxycobalamin and adenosylcobalamin — the methylcobalamin form, which is found in the REMSleep product, is the easiest form for the body to process, absorb, and utilize. Though some people do get adequate levels of methylcobalamin through their diets, many do not; and if their B12 absorption mechanism is not properly functioning and/or their diet does not include adequate B12, the symptoms of their B12 deficiency can be delayed for years, or can be masked as other disease symptoms. It’s important to remember that B12 and D3 are the most commonly diagnosed vitamin deficiencies in the U.S.
In the elderly, deficiency of B12 can cause depression, numbness, pins and needles sensations or a burning feeling, as well as Alzheimer’s symptoms. In extreme and rare cases, it can also cause a swollen tongue and diarrhea. Those suffering from sleep-wake disorder, which includes symptoms such as daytime sleepiness, restless nights and frequent nighttime awakenings, can be treated with the REMSleep product which contains the high-quality, high dose methylcobalamin. Supplementation of B12 often leads to better sleep quality, daytime alertness, increased concentration, and better mood.
Magnesium Ascorbate – This is an excellent molecule because it pairs as two ingredients combined into one molecule – Vitamin C. Vitamin C is a powerful antioxidant that lowers cortisol and fights free radicals which helps the body to move into a state of relaxation. The combined effect of attaching the Ascorbic Acid, or Vitamin C to Magnesium, is that it increases bio-availability, you get the added benefit of additional Magnesium, and Magnesium Ascorbate is defined as a “Buffered Vitamin C,” which means that the Magnesium that’s attached to the Ascorbic Acid helps to reduce any acid or acid reflux that can be produced in some people who simply take the generic Ascorbic Acid Vitamin C. That’s why generic vitamin C is recommended to be taken with food, to avoid the potential acid problem in the stomach. This buffered Vitamin C that’s attached to Magnesium helps the individual feel drowsy more quickly, avoid the acid problem, and can then take the supplement on an empty stomach at bedtime with no gastrointestinal side effects. This will continue to help the individual remain asleep.
Vitamin D3 – The most well-known consequences to not having enough vitamin D (it’s actually a hormone) were associated with bone diseases like rickets, osteoporosis etc, because vitamin D is necessary for proper calcium absorption and utilization. In our modern world, we see the consequences of D deficiency are numerous and these include skeletal diseases, metabolic disorders, menstrual irregularities, autoimmune diseases, cognitive disorders, depression and most importantly, sleep disorders.
Vitamin D is crucial for our overall health and well-being. It helps to build strong bones by working to absorb and utilize calcium throughout the body, it regulates our immune and neuromuscular systems, and even plays a major role in the life cycle of our cells. A vitamin D deficiency can lead to many physical health issues but it also is a leading cause of sleep disorders.
Vitamin E – If you find yourself sitting at your desk during the work day constantly twitching your leg, you likely have Restless Leg Syndrome, or RLS. This is a result of your body’s constant need to exert energy and can be affecting your sleep. A study published in “American Family Physician” indicates vitamin E helps control restless leg syndrome, helping patients fall asleep faster and stay asleep through the night. It also works synergistically with Vitamin C and other antioxidants to help cleanse the body and keep cortisol levels lower.
Melatonin – This is the most common, single sleep ingredient on the market and is almost always found in sleep aids that contain multiple ingredients. With regard to sleep, Melatonin has the potential to be as important as Magnesium when helping to induce and maintain good sleep. It can also have negative and unintended side effects if taken inappropriately or in too high of doses.
“Any person in the sleep world will tell you the same thing: melatonin is not harmless, is vastly overused and should not be used as a sleep aid to treat insomnia,” – Michael Grandner, a sleep researcher at the University of Arizona, told The Huffington Post.
Melatonin is meant to reset the body’s internal clock — for example, it’s appropriate to use the supplement to counter the effects of jet lag, or help someone sleep if they have an unusual work schedule or suffer from a circadian rhythm disorder. It should not be used for general insomnia.
The proper dosage, according to a seminal 2001 study from the Massachusetts Institute of Technology, is 0.3 milligrams. The research was conducted by Richard Wurtman, who pioneered the pharmaceutical use of melatonin as a sleep aid in 1994. Pills and supplements often sell 10 times that suggested amount in a single dose. This can lead to higher plasma melatonin levels the next day, which can cause a “hangover” effect that leaves users groggy.
Any person in the sleep world will tell you the same thing: Melatonin is not harmless, is vastly overused and should not be used as a sleep aid to treat insomnia. Michael Grandner, University of Arizona According to a 2005 meta-analysis of melatonin studies from MIT, also led by Wurtman, researchers found that the widely available high doses of melatonin are ineffective. “After a few days, it stops working,” wrote Wurtman, in a press release accompanying the study. When the brain’s melatonin receptors are exposed to too much of the hormone, they become unresponsive, he said.
Melatonin may also be unsafe for children. David Kennaway, the director of the circadian physiology lab at the University of Adelaide in Australia, told Science Daily that the use of melatonin to treat children’s sleep disorders is “rather alarming.” He said there is “extensive evidence from laboratory studies that melatonin causes changes in multiple physiological systems, including cardiovascular, immune and metabolic systems, as well as reproduction in animals,” and its effects on children’s developing bodies is yet unstudied.
“The word ‘safe’ is used very freely and loosely with this drug,” said Kennaway, “but there have been no rigorous, long-term safety studies of the use of melatonin to treat sleep disorders in children and adolescents.”
Even for adults, the unregulated nature of the supplement gives cause for reconsideration. Although synthetic melatonin is “chemically identical” to natural melatonin, commercially available supplements “often contain fillers, inert and other ingredients that may cause effects that would not be expected with natural melatonin,” Clete Kushida, a sleep researcher at Stanford University School of Medicine, told HuffPost in an email.
“This is a concern that clinicians should relay to patients, especially since the contents of the supplements are not regulated by the FDA,” said Kushida. “And since it’s not regulated by the FDA, the long-term effects/consequences have not been studied in a controlled and systematic manner.”
With this information in mind, and to maintain competitive efficacy in the marketplace, I made a compromise with my product. REMSleep has significantly lower levels of Melatonin than most other sleep aid products, but it does contain slightly higher levels than suggested by these researchers. I took into consideration bio-availability across individuals, the possibility of the person having poorly functioning conversion of serotonin to melatonin, and individuals who have been Melatonin deficient for an extended period of time due to depression and health-related issues. With my research in mind, the information from the doctors above, and what people are generally used to seeing and comfortable buying over the counter, I decided on the dose that is currently in my product and listed in the nutritional facts. I believe with all things considered, the dose now sits at an appropriate, safe, and effective level that will not result in side effects or morning after grogginess.
5HTP (5-Hydroxytryptophan) – When we think of protein, we can think of roughly 20 amino acids that make up a protein. One of those amino acids is called Tryptophan and this amino acid plays a variety of important roles in human health including immune function, cognitive function, feeling of well-being, and proper sleep/wake cycles, etc. Tryptophan is then converted into the serotonin precursor, 5-hydroxytryptophan, or 5HTP, and after 5HTP is converted into serotonin, the serotonin is converted into the hormone melatonin. With regard to supplementation, pure serotonin is not available as an ingredient. The most immediate ingredient that can be supplemented for serotonin creation is 5HTP. By using 5HTP, we can bypass the steps of conversion beginning with the intake of protein, which is then broken down into its individual amino acids, which then go on to convert into all of the other precursors of neurotransmitters, such as 5HTP.
GABA (Gamma Aminobutyric Acid) – Gamma Aminobutyric Acid (GABA), an amino acid, is the major inhibitory neurotransmitter in your central nervous system (CNS). That is, your body uses GABA to dampen nerve activity in your brain, which leads to feelings of calm and relaxation.
Many anti-anxiety medications and sleeping pills, including alprazolam (Xanax) and diazepam (Valium), work by increasing the amount of GABA in your brain. Some natural sedative herbs, such as valerian, also work by increasing GABA. It’s thought that maintaining optimal GABA levels may be imperative for restful sleep and avoiding insomnia.
GABA Is Essential for Deep Sleep
In a healthy night’s sleep, you should progress through the following sleep stages (though not necessarily in this order)
• Stage One, when you’re preparing to drift off
• Stage Two, during which your brainwave activity becomes rapid and rhythmic while your body temperature drops and heart rate slows
• Stage Three, when deep slow brain waves emerge (this is a transition from light sleep to deep sleep)
• Stage Four, also known as delta sleep, this is a deep sleep stage
• Stage Five, or rapid eye movement (REM) sleep, is when most dreaming occurs
Stages three and four, including slow-wave sleep (also known as deep sleep), are incredibly important. Slow- wave sleep is a sleep stage associated with reduced levels of cortisol (a stress hormone) and reduced inflammation.
Deep sleep plays a very special role in strengthening immunological memories of previously encountered pathogens in a way similar to psychological long-term memory retention. This means when you’re well rested with sufficient deep sleep, your immune system is able to mount a much faster and more effective response when an antigen is encountered a second time. The activation of GABA receptors (specifically GABA-A receptor) is known to favor sleep. On the other hand, low levels of GABA are known to interfere with deep sleep, such that people with low levels may wake easily and often throughout the night, missing out on meaningful amounts of this crucial slow-wave sleep.
L-Theanine – L-Theanine is an amino acid found in green and black tea. When given as a supplement in amounts higher than in a cup of tea, studies suggest a number of positive effects, such as improving mental alertness, reducing stress, reducing symptoms of anxiety, and enhancing the quality of sleep — although it does not cause drowsiness nor does it induce sleep.
Proprietary Herbal Blend – Holy Basil Extract, Valerian Root Extract, Kava Kava Powder, Chamomile Powder, Hops Extract, Lemon Balm Leaf Extract, Passionflower Herb Extract, Ashwagandha Root Powder, and Grape Seed Extract – the REMSleep product contains four general components that make it unique from any other sleep aid. These components include: Vitamins, Minerals, Amino Acids, and Herbs, all of which compliment and work synergistically with one another to help enhance a great night’s sleep. The Proprietary Herbal Blend includes 9 ingredients, all of which have been shown to help improve the quality of one’s sleep.
Sleep better, Live Better.
REMSleep© will help you get the deep sleep you need that will ensure you wake up feeling rested and energized! REMSleep©’s combination of 100% natural nutraceuticals work together and interact with receptors in the brain believed to help produce and increase the sleep you need to feel your best!